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ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will boost the level or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has become affiliated with coadministration of ritonavirSince CYP3A4 inhibition elevates ergotamine and caffe